Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC7994172 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Liu Xinwei X Xiang Dulei D Xu Chong C Chai Ruonan R
American journal of cancer research 20210301 3
EIF3m is the latest identified subunit of the eukaryotic translation initiation factor 3 (eIF3), however, its function in malignant tumor is rarely reported. In the current work, we observed that EIF3m was aberrant over-expressed in lung adenocarcinoma (LADC) tissues and cell lines, and the increased EIF3m level was closely related to the poor clinical outcomes of the LADC patients. The gain- and loss-of-function assays demonstrated the proto-oncogenetic potential of EIF3m <i>in vitro</i> and <i ...[more]