Detection methods for SARS-CoV-2 in tissue.

ABSTRACT:

Background

Analyses for the presence of SARS-CoV‑2 in the tissues of COVID-19 patients is important in order to improve our understanding of the disease pathophysiology for interpretation of diagnostic histopathological findings in autopsies, biopsies, or surgical specimens and to assess the potential for occupational infectious hazard.

Material and methods

In this review we identified 136 published studies in PubMed's curated literature database LitCovid on SARS-CoV‑2 detection methods in tissues and evaluated them regarding sources of error, specificity, and sensitivity of the methods, taking into account our own experience.

Results

Currently, no sufficiently specific histomorphological alterations or diagnostic features for COVID-19 are known. Therefore, three appr

SUBMITTER: von Stillfried S 

PROVIDER: S-EPMC7994356 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature