Ontology highlight
ABSTRACT:
SUBMITTER: Iyer KV
PROVIDER: S-EPMC7994818 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Iyer K Venkatesan KV Taubenberger Anna A Zeidan Salma Ahmed SA Dye Natalie A NA Eaton Suzanne S Jülicher Frank F
Nature communications 20210325 1
The levels of nuclear protein Lamin A/C are crucial for nuclear mechanotransduction. Lamin A/C levels are known to scale with tissue stiffness and extracellular matrix levels in mesenchymal tissues. But in epithelial tissues, where cells lack a strong interaction with the extracellular matrix, it is unclear how Lamin A/C is regulated. Here, we show in epithelial tissues that Lamin A/C levels scale with apico-basal cell compression, independent of tissue stiffness. Using genetic perturbations in ...[more]