Impact of the Histidine-Containing Phosphocarrier Protein HPr on Carbon Metabolism and Virulence in Staphylococcus aureus.
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SUBMITTER: Patzold L
PROVIDER: S-EPMC7996215 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Impact of the Histidine-Containing Phosphocarrier Protein HPr on Carbon Metabolism and Virulence in <i>Staphylococcus aureus</i>.
Pätzold Linda L Brausch Anne-Christine AC Bielefeld Evelyn-Laura EL Zimmer Lisa L Somerville Greg A GA Bischoff Markus M Gaupp Rosmarie R
Microorganisms 20210224 3
Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram-positive bacteria, catabolite control protein A (CcpA) and the histidine-containing phosphocarrier protein HPr (encoded by <i>ptsH</i>) are the predominant mediators of CCR. In addition to modulating CcpA activity, HPr is essential for glucose import via the phosphotransferase system. While the regulatory functions of CcpA in <i>Staphylococcus aureu ...[more]
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