Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7997921 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Wang Xiaohui X Lin Xiang X Zheng Zihan Z Lu Bingtai B Wang Jun J Tan Andy Hee-Meng AH Zhao Meng M Loh Jia Tong JT Ng Sze Wai SW Chen Qian Q Xiao Fan F Huang Enyu E Ko King-Hung KH Huang Zhong Z Li Jingyi J Kok Kin-Hang KH Lu Gen G Liu Xiaohui X Lam Kong-Peng KP Liu Wanli W Zhang Yuxia Y Yuen Kwok-Yung KY Mak Tak Wah TW Lu Liwei L
Nature communications 20210326 1
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ T cells to produce interleukin 17 A (IL-17A) for early protection against H1N1 influenza infection. During infection, the lung γδ T cell pool is constantly supplemented by thymic output, with recent emigrants infiltrating into the lung parenchyma and airway to acquire tissue-resident fea ...[more]