Ontology highlight
ABSTRACT:
SUBMITTER: Strati A
PROVIDER: S-EPMC7998407 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Strati Areti A Nikolaou Michail M Georgoulias Vassilis V Lianidou Evi S ES
Diagnostics (Basel, Switzerland) 20210314 3
In metastatic breast cancer (MBC) the molecular characterization of circulating tumor cells (CTCs) provides a unique tool to understand metastasis-biology and therapy-resistance. We evaluated the prognostic significance of gene expression in EpCAM<sup>(+)</sup> CTCs in 46 MBC patients based on a long follow-up. We selected a panel consisting of stem cell markers (<i>CD24</i>, <i>CD44</i>, <i>ALDH1</i>), the mesenchymal marker <i>TWIST1</i>, receptors (<i>ESR1</i>, <i>PGR</i>, <i>HER2</i>, <i>EGF ...[more]