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COVID-19 Vaccine Failure in a Patient with Multiple Sclerosis on Ocrelizumab.


ABSTRACT: Vaccines will play a key role in ending the COVID-19 pandemic. Vaccination against infections remains an important part of the management of patients with multiple sclerosis. However, there are limited data about the safety and efficacy of the currently available COVID-19 mRNA vaccines in patients with multiple sclerosis receiving concurrent immunosuppressive therapies. Patients on B cell depleting therapy such as ocrelizumab have an attenuated vaccine response. We report the first case of COVID-19 vaccine failure in a patient with relapsing-remitting multiple sclerosis on B cell depleting therapy, ocrelizumab. We offer suggestions to improve vaccine efficacy in these patients.

SUBMITTER: Chilimuri S 

PROVIDER: S-EPMC8002140 | biostudies-literature |

REPOSITORIES: biostudies-literature

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