Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double-blind, controlled trial.

ABSTRACT:

Background

Lidocaine and magnesium sulfate have become increasingly utilized in general anesthesia. The present study evaluated the effects of these drugs, isolated or combined, on hemodynamic parameters as well as on the cisatracurium-induced neuromuscular blockade (NMB).

Methods

At a university hospital, 64 patients, ASA physical status I and II, undergoing elective surgery with similar pain stimuli were randomly assigned to four groups. Patients received a bolus of lidocaine and magnesium sulfate before the tracheal intubation and a continuous infusion during the operation as follows: 3 mg.kg^- 1 and 3 mg.kg^- 1.h^- 1 (lidocaine - L group), 40 mg.kg^- 1 and 20 mg.kg^- 1.h^- 1 (magnesium - M group), equal doses of

SUBMITTER: Paula-Garcia WN 

PROVIDER: S-EPMC8004390 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature