Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells.

ABSTRACT: Arginine deprivation therapy (ADT) is a new metabolic targeting approach with high therapeutic potential for various solid cancers. Combination of ADT with low doses of the natural arginine analog canavanine effectively sensitizes malignant cells to irradiation. However, the molecular mechanisms determining the sensitivity of intrinsically non-auxotrophic cancers to arginine deficiency are still poorly understood. We here show for the first time that arginine deficiency is accompanied by global metabolic changes and protein/membrane breakdown, and results in the induction of specific, more or less pronounced (severe vs. mild) ER stress responses in head and neck squamous cell carcinoma (HNSCC) cells that differ in their intrinsic ADT sensitivity. Combination of ADT with canavanine triggere

SUBMITTER: Chen O 

PROVIDER: S-EPMC8004506 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature