Needle Trap Device-GC-MS for Characterization of Lung Diseases Based on Breath VOC Profiles.

ABSTRACT: Volatile organic compounds (VOCs) have been assessed in breath samples as possible indicators of diseases. The present study aimed to quantify 29 VOCs (previously reported as potential biomarkers of lung diseases) in breath samples collected from controls and individuals with lung cancer, chronic obstructive pulmonary disease and asthma. Besides that, global VOC profiles were investigated. A needle trap device (NTD) was used as pre-concentration technique, associated to gas chromatography-mass spectrometry (GC-MS) analysis. Univariate and multivariate approaches were applied to assess VOC distributions according to the studied diseases. Limits of quantitation ranged from 0.003 to 6.21 ppbv and calculated relative standard deviations did not exceed 10%. At least 15 of the quantified targets

SUBMITTER: Monedeiro F 

PROVIDER: S-EPMC8004837 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature