Hyperkalemia and Acute Kidney Injury with Spironolactone Use Among Patients with Heart Failure.

ABSTRACT:

Objective

To quantify the risk of hyperkalemia and acute kidney injury (AKI) when spironolactone use is added on to loop diuretic use among patients with heart failure, and to evaluate whether the risk is modified by level of kidney function.

Methods

We identified 17,110 patients with heart failure treated with loop diuretics between January 1, 2004, and December 31, 2016 within the Geisinger Health System. We estimated the incidence of hyperkalemia and AKI associated with spironolactone initiation, and used target trial emulation methods to minimize confounding by indication.

Results

During a mean follow-up of 134 mo, 3229 of 17,110 patients (18.9%) initiated spironolactone. Incidence rates of hyperkalemia and AKI in patients using spironolactone with a loop diuretic

SUBMITTER: Secora AM 

PROVIDER: S-EPMC8005315 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature