Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration.
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ABSTRACT:
SUBMITTER: Giunta M
PROVIDER: S-EPMC8005747 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration.
Giunta Marcello M Solje Eino E Gardoni Fabrizio F Borroni Barbara B Benussi Alberto A
Journal of experimental pharmacology 20210324
Frontotemporal dementia is a clinically, genetically and pathologically heterogeneous neurodegenerative disorder, enclosing a wide range of different pathological entities, associated with the accumulation of proteins such as tau and TPD-43. Characterized by a high hereditability, mutations in three main genes, <i>MAPT, GRN</i> and <i>C9orf72</i>, can drive the neurodegenerative process. The connection between different genes and proteinopathies through specific mechanisms has shed light on the ...[more]
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