Integrin Alpha V in Urine: A Novel Noninvasive Marker for Prostate Cancer Detection.
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ABSTRACT: Materials and methods
Urinary ITGAV expression was determined by Western blot analysis and quantified by ELISA in urine from men with PCa (n = 47), benign prostate hyperplasia (n = 42) and age-matched controls (n = 22).Results
The level of ITGAV protein was significantly lower in PCa urine samples as compared to those in the control group (p < 0.00001). The decrease of ITGAV in urine was highly predictive of PCa with 91.5% sensitivity, 91.4% specificity, 0.93 area under the ROC curve, and its specificity was better than that of serum PSA.Conclusion
Urinary ITGAV provides a novel noninvasive biomarker with high specificity.
SUBMITTER: Zemskova MY
PROVIDER: S-EPMC8006463 | biostudies-literature |
REPOSITORIES: biostudies-literature
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