Elements and evolutionary determinants of genomic divergence between paired primary and metastatic tumors.

ABSTRACT: Can metastatic-primary (M-P) genomic divergence measured from next generation sequencing reveal the natural history of metastatic dissemination? This remains an open question of utmost importance in facilitating a deeper understanding of metastatic progression, and thereby, improving its prevention. Here, we utilize mathematical and computational modeling to tackle this question as well as to provide a framework that illuminates the fundamental elements and evolutionary determinants of M-P divergence. Our framework facilitates the integration of sequencing detectability of somatic variants, and hence, paves the way towards bridging the measurable between-tumor heterogeneity with analytical modeling and interpretability. We show that the number of somatic variants of the metastatic seeding

SUBMITTER: Sun R 

PROVIDER: S-EPMC8007046 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature