Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC8007160 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.
Wang Zhen Z Zhou Hong H Zheng Huaping H Zhou Xikun X Shen Guobo G Teng Xiu X Liu Xiao X Zhang Jun J Wei Xiaoqiong X Hu Zhonglan Z Zeng Fanlian F Hu Yawen Y Hu Jing J Wang Xiaoyan X Chen Shuwen S Cheng Juan J Zhang Chen C Gui Yiyue Y Zou Song S Hao Yan Y Zhao Qixiang Q Wu Wenling W Zhou Yifan Y Cui Kaijun K Huang Nongyu N Wei Yuquan Y Li Wei W Li Jiong J
Autophagy 20200216 2
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. The impairment of autophagic flux alleviated psoriasisform inflammation. We also found that an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 ...[more]
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