Ontology highlight
ABSTRACT:
SUBMITTER: Pounot K
PROVIDER: S-EPMC8008261 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Pounot Kevin K Grime Geoffrey W GW Longo Alessandro A Zamponi Michaela M Noferini Daria D Cristiglio Viviana V Seydel Tilo T Garman Elspeth F EF Weik Martin M Foderà Vito V Schirò Giorgio G
Biophysical journal 20210203 5
Protein aggregation is a widespread process leading to deleterious consequences in the organism, with amyloid aggregates being important not only in biology but also for drug design and biomaterial production. Insulin is a protein largely used in diabetes treatment, and its amyloid aggregation is at the basis of the so-called insulin-derived amyloidosis. Here, we uncover the major role of zinc in both insulin dynamics and aggregation kinetics at low pH, in which the formation of different amyloi ...[more]