Ontology highlight
ABSTRACT:
SUBMITTER: Kneller DW
PROVIDER: S-EPMC8009097 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Kneller Daniel W DW Phillips Gwyndalyn G Weiss Kevin L KL Zhang Qiu Q Coates Leighton L Kovalevsky Andrey A
Journal of medicinal chemistry 20210323 8
The main protease (3CL M<sup>pro</sup>) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is an essential enzyme for viral replication with no human counterpart, making it an attractive drug target. To date, no small-molecule clinical drugs are available that specifically inhibit SARS-CoV-2 M<sup>pro</sup>. To aid rational drug design, we determined a neutron structure of M<sup>pro</sup> in complex with the α-ketoamide inhibitor telaprevir at near ...[more]