Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer.
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ABSTRACT: A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a regio- and diastereoselective Pd-catalyzed C(sp3)H-arylation of the corresponding 2S,6S-(6-methoxymorpholin-2-yl)carboxylic acid, readily available from glucose. According to the computational prevision and confirmed by IR and NMR data, the insertion of 3-Ar-β-Morph in a model foldamer represents a way to stabilize a PPII-like helix through the presence of two γ-turns, secondary structure motifs induced by the morpholine ring, and the trans-tertiary amide bond.
SUBMITTER: Vaghi F
PROVIDER: S-EPMC8009597 | biostudies-literature |
REPOSITORIES: biostudies-literature
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