Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study.

ABSTRACT:

Background

Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission.We hypothesise that seropositivity provides more accurate household attack rates than RT-PCR. Here, we investigated the importance of age in household transmission dynamics.

Methods

We enroled 112 households (291 participants) in a case-ascertained study in Bergen, Norway from 28th February to 4th April 2020, collecting demographic and clinical data from index patients and household members. SARS-CoV-2-specific antibodies were measured in sera collected 6-8 weeks after index patient nasopharyngeal testing to define household attack rates.

Findings

The overall attack rate was 45% (95% CI 38-53) assessed by

SUBMITTER: Kuwelker K 

PROVIDER: S-EPMC8009692 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature