Comparative efficacy of first-line therapeutic interventions for achalasia: a systematic review and network meta-analysis.

ABSTRACT:

Background

Several interventions with variable efficacy are available as first-line therapy for patients with achalasia. We assessed the comparative efficacy of different strategies for management of achalasia, through a network meta-analysis combining direct and indirect treatment comparisons.

Methods

We identified six randomized controlled trials in adults with achalasia that compared the efficacy of pneumatic dilation (PD; n = 260), laparoscopic Heller myotomy (LHM; n = 309), and peroral endoscopic myotomy (POEM; n = 176). Primary efficacy outcome was 1-year treatment success (patient-reported improvement in symptoms based on validated scores); secondary efficacy outcomes were 2-year treatment success and physiologic improvement; safety outcomes were risk of gastroesophag

SUBMITTER: Facciorusso A 

PROVIDER: S-EPMC8011535 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature