Ontology highlight
ABSTRACT:
SUBMITTER: Inizan C
PROVIDER: S-EPMC8011692 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Inizan Catherine C Minier Marine M Prot Matthieu M O'Connor Olivia O Forfait Carole C Laumond Sylvie S Marois Ingrid I Biron Antoine A Gourinat Ann-Claire AC Goujart Marie-Amélie MA Descloux Elodie E Sakuntabhai Anavaj A Tarantola Arnaud A Simon-Lorière Etienne E Dupont-Rouzeyrol Myrielle M
Emerging microbes & infections 20211201 1
Compared to the previous 2013-2014 outbreak, dengue 2016-2017 outbreak in New Caledonia was characterized by an increased number of severe forms associated with hepatic presentations. In this study, we assessed the virological factors associated with this enhanced severity. Whole-genome sequences were retrieved from dengue virus (DENV)-1 strains collected in 2013-2014 and from severe and non-severe patients in 2016-2017. Fitness, hepatic tropism and cytopathogenicity of DENV 2016-2017 strains we ...[more]