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A novel allele, HLA-C*15:227, identified when typing COVID-19 patients.

ABSTRACT: HLA-C*15:227 differs from HLA-C*15:02:01:01 by a single nonsynonymous change (368A → G Tyrosine 99 to Cysteine).

SUBMITTER: Cheranev V

PROVIDER: S-EPMC8013338 | biostudies-literature |

REPOSITORIES: biostudies-literature

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A novel HLA-C*15 allele

Project description:A novel HLA-C*15 allele

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Project description:Genetic differences among individuals could affect the clinical presentations and outcomes of COVID-19. Human Leukocyte Antigens are associated with COVID-19 susceptibility, severity, and prognosis. This study aimed to identify HLA-B and -C genotypes among 69 Egyptian patients with COVID-19 and correlate them with disease outcomes and other clinical and laboratory data. HLA-B and -C typing was performed using Luminex-based HLA typing kits. Forty patients (58%) had severe COVID-19; 55% of these patients died, without reported mortality in the moderate group. The alleles associated with severe COVID-19 were HLA-B*41, -B*42, -C*16, and -C*17, whereas HLA-B*15, -C*7, and -C*12 were significantly associated with protection against mortality. Regression analysis showed that HLA-B*15 was the only allele associated with predicted protection against mortality, where the likelihood of survival increased with HLA-B*15 (P < 0.001). Patient survival was less likely to occur with higher total leukocytic count, ferritin, and creatinine levels. This study provides interesting insights into the association between HLA class I alleles and protection from or severity of COVID-19 through immune response modulation. This is the first study to investigate this relationship in Egyptian patients. More studies are needed to understand how HLA class I alleles interact and affect Cytotoxic T lymphocytes and natural killer cell function.

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Characterization of the novel HLA-DQA1*01:89 allele by sequencing-based typing.

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Characterization of the novel HLA-A*11:422 allele by sequencing-based typing.

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Characterization of the novel HLA-DRB1*11:04:21 allele by sequencing-based typing.

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Characterization of the novel HLA-C*17:01:18 allele by sequencing-based typing.

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