Ontology highlight
ABSTRACT: Aim
To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study.Materials and methods
This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7 days of admission. Stabilized weights were computed for patients based on propensity score (DPP-4 inhibitors users vs. non-users) and were used in multivariable logistic regression models to estimate the average treatment effect in the treated as inverse probability of treatment weighting (IPTW).Results
Five hundred and ninety-six participants were under DPP-4 inhibitors before admission to hospital (24.3%). The primary outcome occurred at similar rates in users and non-users of DPP-4 inhibitors (27.7% vs. 28.6%; p = .68). In propensity analysis, the IPTW-adjusted models showed no significant association between the use of DPP-4 inhibitors and the primary outcome by Day 7 (OR [95% CI]: 0.95 [0.77-1.17]) or Day 28 (OR [95% CI]: 0.96 [0.78-1.17]). Similar neutral findings were found between use of DPP-4 inhibitors and the risk of tracheal intubation and death.Conclusions
These data support the safety of DPP-4 inhibitors for diabetes management during the COVID-19 pandemic and they should not be discontinued.
SUBMITTER: Roussel R
PROVIDER: S-EPMC8013481 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Roussel Ronan R Darmon Patrice P Pichelin Matthieu M Goronflot Thomas T Abouleka Yawa Y Ait Bachir Leila L Allix Ingrid I Ancelle Deborah D Barraud Sara S Bordier Lyse L Carlier Aurélie A Chevalier Nicolas N Coffin-Boutreux Christine C Cosson Emmanuel E Dorange Anne A Dupuy Olivier O Fontaine Pierre P Fremy Bénédicte B Galtier Florence F Germain Natacha N Guedj Anne-Marie AM Larger Etienne E Laugier-Robiolle Stéphanie S Laviolle Bruno B Ludwig Lisa L Monier Arnaud A Montanier Nathanaëlle N Moulin Philippe P Moura Isabelle I Prevost Gaëtan G Reznik Yves Y Sabbah Nadia N Saulnier Pierre-Jean PJ Serusclat Pierre P Vatier Camille C Wargny Matthieu M Hadjadj Samy S Gourdy Pierre P Cariou Bertrand B
Diabetes, obesity & metabolism 20210216 5
<h4>Aim</h4>To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study.<h4>Materials and methods</h4>This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilati ...[more]