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Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.

ABSTRACT: During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.

SUBMITTER: Ortillon M

PROVIDER: S-EPMC8014094 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.

Ortillon Marine M Coudereau Remy R Cour Martin M Rimmelé Thomas T Godignon Marine M Gossez Morgane M Yonis Hodane H Argaud Laurent L Lukaszewicz Anne-Claire AC Venet Fabienne F Monneret Guillaume G

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20210205 5

During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may b ...[more]

PMID: 33547747

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