Dataset Information

Increased vulnerability to COVID-19 in chronic kidney disease.

ABSTRACT:

Background

The significance of chronic kidney disease on susceptibility to COVID-19 and subsequent outcomes remains unaddressed.

Objective

To investigate the association of estimated glomerular filtration rate (eGFR) on risk of contracting COVID-19 and subsequent adverse outcomes.

Methods

Rates of hospital-diagnosed COVID-19 were compared across strata of eGFR based on conditional logistic regression using a nested case-control framework with 1:4 matching of patients diagnosed with COVID-19 with controls from the Danish general population on age, gender, diabetes and hypertension. Risk of subsequent severe COVID-19 or death was assessed in a cohort study with comparisons across strata of eGFR based on adjusted Cox regression models with G-computation of results to determine 60-day risk standardized to the distribution of risk factors in the sample.

Results

Estimated glomerular filtration rate was inversely associated with rate of hospital-diagnosed COVID-19: eGFR 61-90 mL/min/1.73m² HR 1.13 (95% CI 1.03-1.25), P = 0.011; eGFR 46-60 mL/min/1.73m² HR 1.26 (95% CI 1.06-1.50), P = 0.008; eGFR 31-45 mL/min/1.73m² HR 1.68 (95% CI 1.34-2.11), P < 0.001; and eGFR ≤ 30 mL/min/1.73m² 3.33 (95% CI 2.50-4.42), P < 0.001 (eGFR > 90 mL/min/1.73m² as reference), and renal impairment was associated with progressive increase in standardized 60-day risk of death or severe COVID-19; eGFR > 90 mL/min/1.73m² 13.9% (95% CI 9.7-15.0); eGFR 90-61 mL/min/1.73m² 16.1% (95% CI 14.5-17.7); eGFR 46-60 mL/min/1.73m² 17.8% (95% CI 14.7-21.2); eGFR 31-45 mL/min/1.73m² 22.6% (95% CI 18.2-26.2); and eGFR ≤ 30 mL/min/1.73m² 23.6% (95% CI 18.1-29.1).

Conclusions

Renal insufficiency was associated with progressive increase in both rate of hospital-diagnosed COVID-19 and subsequent risk of adverse outcomes. Results underscore a possible vulnerability associated with impaired renal function in relation to COVID-19.

SUBMITTER: Carlson N

PROVIDER: S-EPMC8014284 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

Increased vulnerability to COVID-19 in chronic kidney disease.

Carlson N N Nelveg-Kristensen K-E KE Nelveg-Kristensen K-E KE Freese Ballegaard E E Feldt-Rasmussen B B Hornum M M Kamper A-Lise AL Gislason G G Torp-Pedersen C C

Journal of internal medicine 20210210 1

<h4>Background</h4>The significance of chronic kidney disease on susceptibility to COVID-19 and subsequent outcomes remains unaddressed.<h4>Objective</h4>To investigate the association of estimated glomerular filtration rate (eGFR) on risk of contracting COVID-19 and subsequent adverse outcomes.<h4>Methods</h4>Rates of hospital-diagnosed COVID-19 were compared across strata of eGFR based on conditional logistic regression using a nested case-control framework with 1:4 matching of patients diagno ...[more]

PMID: 33452733

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Dataset Information

Increased vulnerability to COVID-19 in chronic kidney disease.

Background

Objective

Methods

Results

Conclusions

Publications

Increased vulnerability to COVID-19 in chronic kidney disease.

Similar Datasets

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