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ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City.


ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities.

Study design and methods

The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146/4968) all-cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in-hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause-specific hazard ratios (csHRs) for in-hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models.

Results

Type A blood was associated with the increased cause-specific hazard of death among COVID-19 patients compared to type O (HR = 1.17, 1.02-1.33, p = .02) and type B (HR = 1.32,1.10-1.58, p = .003).

Conclusions

Our study shows that ABO histo-blood group type is associated with the risk of in-hospital death in COVID-19 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2.

SUBMITTER: Szymanski J 

PROVIDER: S-EPMC8014690 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City.

Szymanski James J   Mohrmann Laurel L   Carter Jamal J   Nelson Randin R   Chekuri Sweta S   Assa Andrei A   Spund Brian B   Reyes-Gil Morayma M   Uehlinger Joan J   Baron Sarah S   Paroder Monika M  

Transfusion 20210305 4


<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities.<h4>Study design and methods</h4>The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a posi  ...[more]

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