ABSTRACT: Turmeric (Curcuma longa L.) has been used as a spice and a medicinal herb since ancient times. The main active ingredient of turmeric is curcumin, a polyphenol that helps prevent and control neurological, respiratory, cardiovascular, metabolic, inflammatory, and autoimmune diseases and some cancers. However, curcumin has drawbacks such as low water-solubility, poor absorption, fast metabolism, quick systemic elimination, low bioavailability, poor pharmacokinetics, low stability, and low penetration targeting efficacy. To overcome these drawbacks, a common method used is encapsulating curcumin in nanocarriers for targeted delivery. However, the degraded products of nanocarriers have raised concerns. In this research, we synthesized nanoparticles of curcumin, nanocurcumin without using nanocarriers. To do so, curcumin was soxhlet extracted from raw turmeric rhizome. The stock solutions of different curcumin concentrations prepared in dichloromethane were added to boiling water at different flow rates and sonicated for different time intervals. An average particle size of 82 ± 04 nm was obtained with 5.00 mg/mL stock solution concentration, at 0.10 mL/min flow rate and 30 min sonication time. The particle size tends to increase with the flow rate and the concentration of curcumin in the stock solution but decreases with the sonication time. X-ray diffraction shows sharp and intense diffraction peaks for curcumin, indicating its identity and high crystallinity, but nanocurcumins are amorphous. Fourier-transform infrared spectroscopy spectra confirm the presence of all the functional groups of curcumin in nanocurcumin. Transmission electron microscopy and scanning electron microscopy images show the perfectly spherical morphology of nanocurcumin. Although curcumin is not water-soluble, nano-curcumin formulations are freely dispersible in water.
