Identification of the angiogenesis related genes for predicting prognosis of patients with gastric cancer.

ABSTRACT:

Introduction

Angiogenesis is a key factor in promoting tumor growth, invasion and metastasis. In this study we aimed to investigate the prognostic value of angiogenesis-related genes (ARGs) in gastric cancer (GC).

Methods

mRNA sequencing data with clinical information of GC were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. The differentially expressed ARGs between normal and tumor tissues were analyzed by limma package, and then prognosis‑associated genes were screened using Cox regression analysis. Nine angiogenesis genes were identified as crucially related to the overall survival (OS) of patients through least absolute shrinkage and selection operator (LASSO) regression. The prognostic model and corresponding nomograms we

SUBMITTER: Zheng S 

PROVIDER: S-EPMC8017607 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature