Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocytes usually express fibroblast growth factor receptor 4 (FGFR4), but not its ligand, fibroblast growth factor 19 (FGF19). A subtype of hepatocellular carcinoma (HCC) expresses FGF19, which activates the FGFR4 signaling pathway that induces cell proliferation. FGFR4 inhibitors that target this mechanism are under clinical development for the treatment of HCCs with FGF19 amplification or FGFR4 overexpression. Src plays an essential role in the FGFR1 and FGFR2 signaling pathways. However, it is yet to be understood whether Src has any role in the FGF19-FGFR4 pathway in HCCs. In this study, we aimed to elucidate the role of Src in the FGF19-FGFR4 axis in HCC.

Methods

3 HCC cell lines expressing both FGF19 and FGFR4 were selected. The expression of each protein

SUBMITTER: Shin JY 

PROVIDER: S-EPMC8017611 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature