Ontology highlight
ABSTRACT:
SUBMITTER: de Alwis R
PROVIDER: S-EPMC8019652 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
de Alwis Ruklanthi R Gan Esther S ES Chen Shiwei S Leong Yan Shan YS Tan Hwee Cheng HC Zhang Summer L SL Yau Clement C Low Jenny G H JGH Kalimuddin Shirin S Matsuda Daiki D Allen Elizabeth C EC Hartman Paula P Park Kyoung-Joo Jenny KJ Alayyoubi Maher M Bhaskaran Hari H Dukanovic Adrian A Bao Yanjie Y Clemente Brenda B Vega Jerel J Roberts Scott S Gonzalez Jose A JA Sablad Marciano M Yelin Rodrigo R Taylor Wendy W Tachikawa Kiyoshi K Parker Suezanne S Karmali Priya P Davis Jared J Sullivan Brian M BM Sullivan Sean M SM Hughes Steve G SG Chivukula Pad P Ooi Eng Eong EE
Molecular therapy : the journal of the American Society of Gene Therapy 20210405 6
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based replicon and the SARS-CoV-2 full-length spike glycoprotein. Translation of the replicon produces a replicase complex that amplifies and prolongs SARS-CoV-2 spike glycoprotein expression. A single prime vaccination in mice led to robust antibody responses, with neutralizing antibody titers increasing up to day 60. Activation of cel ...[more]