Interferon-Lambda 1 Inhibits Staphylococcus aureus Colonization in Human Primary Keratinocytes.
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ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC8019897 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Interferon-Lambda 1 Inhibits <i>Staphylococcus aureus</i> Colonization in Human Primary Keratinocytes.
Wu Xia X Zhao Yan Y Gu Ying Y Li Kun K Wang Xiaojie X Zhang Jianzhong J
Frontiers in pharmacology 20210322
Atopic dermatitis (AD) is a common inflammatory skin disease. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) colonization in skin lesions occurs in approximately 70% of AD patients. It has been found that IFN-λ1 can inhibit the colonization of <i>S. aureus</i> in normal human nasal mucosa. IFN-λ1 can increase IL-28RA in infected human keratinocytes. In this study, we found that IFN-λ1 can increase mRNA expression of FLG and antimicrobial peptides (AMPs) and inhibit TSLP mRNA expression in infec ...[more]
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