Dataset Information

Association of serum 25-hydroxy vitamin D with obesity-related indices in Chinese adults: A cross-sectional study.

ABSTRACT: Obesity has been a well-known risk factor of low-level serum vitamin D. Compared with the traditional obesity-related indicator (body mass index, BMI), associations for two novel anthropometric indices, a body shape index (ABSI) and body roundness index (BRI) with vitamin D deficiency or insufficiency, still remain unclear. This study aimed to assess the associations of serum 25-hydroxy vitamin D (25(OH)D) status with these three obesity-related indices among Chinese adults. A total of 1666 individuals were included. Anthropometric measurements were performed to calculate the indices, and fasting blood was collected to determine serum 25(OH)D deficiency (<12 ng/ml) and insufficiency (12-20 ng/ml). Deficiency or insufficiency of 25(OH)D was found in 37.5% and 43.1% of the participants, respectively. After adjustment for potential confounders, a significantly increased prevalence of 25(OH)D deficiency was observed for higher ABSI (OR _{Q4 vs Q1} 2.334, 95% CI 1.458-3.734; p _trend = 0.002) and BRI (OR _{Q4 vs Q1} 2. 215, 95%CI 1.365-3.594; p _trend = 0.010), and for higher BMI in men. Regarding 25(OH)D insufficiency, a significant association was also found for ABSI (OR _{Q4 vs Q1} 2.372, 95%CI 1.558-3.612; p _trend = 0.001). The area under the ROC of ABSI (0.731, 95%CI 0.687-0.774) for predicting a low level of 25(OH)D was significantly larger than that of BMI (0.695, 95%CI 0.649-0.741) in men, but not in women. A positive association between obesity and lower 25(OH)D serum concentration was found among Chinese adults. Besides BMI, novel obesity-related indicator, ABSI and BRI were associated with lower serum 25(OH)D to some extent, and further studies are needed to clarify their potential to be used as screening tools in clinical practice.

SUBMITTER: Ren Z

PROVIDER: S-EPMC8020955 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:BackgroundLower serum 25-hydroxyvitamin D [25(OH)D] is associated with greater adiposity and adverse cardiometabolic risk profile. The evidence is inconsistent among South Asian Indians. We aimed to examine associations between 25(OH)D and cardiovascular (CVD) risk markers in a rural and urban cohort from South India.Subjects/methodsIn this cross sectional study, 373 individuals (men, n = 205) underwent detailed CVD risk marker assessment including anthropometry [body mass index (BMI), waist, (WC) and hip circumferences (HC)], body composition analysis using dual energy x-ray absorptiometry (DXA), blood pressure and biochemical analysis (glucose, insulin and lipids). The distribution of CVD risk factors were compared across serum 25(OH)D levels, stratified as deficiency (<20 ng/ml), insufficiency (20 to 29 ng/ml) and normal (≥30 ng/ml) levels. Multiple regression analysis, adjusting for potential confounders, was used to study associations of 25(OH)D with adiposity and cardiometabolic traits.ResultsThe mean and standard deviation (SD) of age, BMI and 25(OH)D levels were 41.4 (1.1) years, 25.5 (4.8) kg/m2 and 23.4 (10.4) ng/ml respectively. The prevalence of 25(OH)D deficiency was 39.9% in this cohort. Individuals in the 25(OH)D deficiency category had significantly higher mean (SD) BMI [26.6 (5.1) kg/m2], waist circumference [89.9 (12.5) cm] and total fat mass [20.6 (7.9) kg] compared with the Vitamin D sufficient group [BMI: 24.0 (4.4); WC 84.7 (12.0); total fat mass: 15.2 (6.8)]. Significantly inverse associations were observed with DXA measured total and regional fat depots with 25(OH)D levels, while anthropometric indices of adiposity showed significant inverse association only in women. After adjusting for total fat mass, no significant associations were observed between 25(OH)D and the cardiometabolic traits.ConclusionsOur results confirm that lower 25(OH)D is independently associated with both total and regional adiposity, but not with cardiometabolic traits, in this population.

Dataset Information

Association of serum 25-hydroxy vitamin D with obesity-related indices in Chinese adults: A cross-sectional study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets