Unknown

Dataset Information

0

PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis.


ABSTRACT: One of the most fundamental and challenging questions in the field of cancer is how immunity is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified the tumor suppressor PDZ-LIM domain-containing protein 2 (PDLIM2) as a checkpoint of alveolar macrophages (AMs) important for lung tumor suppression. During lung tumorigenesis, PDLIM2 expression in AMs is downregulated by ROS-activated transcription repressor BTB and CNC homology 1 (BACH1). PDLIM2 downregulation leads to constitutive activation of the transcription factor STAT3, driving AM protumorigenic polarization/activation and differentiation from monocytes attracted from the circulation to suppress cytotoxic T lymphocytes and promote lung cancer. PDLIM2 downregulation also decreases AM phagocytosis. These findings establish ROS/BACH1/PDLIM2/STAT3 as a signaling pathway driving AMs for lung tumor promotion.

SUBMITTER: Li L 

PROVIDER: S-EPMC8021114 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10524974 | biostudies-literature
| S-EPMC6876573 | biostudies-literature
| S-EPMC10562548 | biostudies-literature
| S-EPMC3404470 | biostudies-literature
| S-EPMC5992816 | biostudies-literature
| S-EPMC3871220 | biostudies-literature
| S-EPMC5980415 | biostudies-literature
| S-EPMC5367626 | biostudies-literature
| S-EPMC3209831 | biostudies-other
| S-EPMC3013277 | biostudies-other