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Crossmodal interactions in audiovisual emotion processing.

ABSTRACT: Emotion in daily life is often expressed in a multimodal fashion. Consequently emotional information from one modality can influence processing in another. In a previous fMRI study we assessed the neural correlates of audio-visual integration and found that activity in the left amygdala is significantly attenuated when a neutral stimulus is paired with an emotional one compared to conditions where emotional stimuli were present in both channels. Here we used dynamic causal modelling to investigate the effective connectivity in the neuronal network underlying this emotion presence congruence effect. Our results provided strong evidence in favor of a model family, differing only in the interhemispheric interactions. All winning models share a connection from the bilateral fusiform gyrus (FFG) into the left amygdala and a non-linear modulatory influence of bilateral posterior superior temporal sulcus (pSTS) on these connections. This result indicates that the pSTS not only integrates multi-modal information from visual and auditory regions (as reflected in our model by significant feed-forward connections) but also gates the influence of the sensory information on the left amygdala, leading to attenuation of amygdala activity when a neutral stimulus is integrated. Moreover, we found a significant lateralization of the FFG due to stronger driving input by the stimuli (faces) into the right hemisphere, whereas such lateralization was not present for sound-driven input into the superior temporal gyrus. In summary, our data provides further evidence for a rightward lateralization of the FFG and in particular for a key role of the pSTS in the integration and gating of audio-visual emotional information.

SUBMITTER: Muller VI

PROVIDER: S-EPMC8022349 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The visual color-word Stroop task is widely used in clinical and research settings as a measure of cognitive control. Numerous neuroimaging studies have used color-word Stroop tasks to investigate the neural resources supporting cognitive control, but to our knowledge all have used unimodal (typically visual) Stroop paradigms. Thus, it is possible that this classic measure of cognitive control is not capturing the resources involved in multisensory cognitive control. The audiovisual integration and crossmodal correspondence literatures identify regions sensitive to congruency of auditory and visual stimuli, but it is unclear how these regions relate to the unimodal cognitive control literature. In this study we aimed to identify brain regions engaged by crossmodal cognitive control during an audiovisual color-word Stroop task, and how they relate to previous unimodal Stroop and audiovisual integration findings. First, we replicated previous behavioral audiovisual Stroop findings in an fMRI-adapted audiovisual Stroop paradigm: incongruent visual information increased reaction time towards an auditory stimulus and congruent visual information decreased reaction time. Second, we investigated the brain regions supporting cognitive control during an audiovisual color-word Stroop task using fMRI. Similar to unimodal cognitive control tasks, a left superior parietal region exhibited an interference effect of visual information on the auditory stimulus. This superior parietal region was also identified using a standard audiovisual integration localizing procedure, indicating that audiovisual integration resources are sensitive to cognitive control demands. Facilitation of the auditory stimulus by congruent visual information was found in posterior superior temporal cortex, including in the posterior STS which has been found to support audiovisual integration. The dorsal anterior cingulate cortex, often implicated in unimodal Stroop tasks, was not modulated by the audiovisual Stroop task. Overall the findings indicate that an audiovisual color-word Stroop task engages overlapping resources with audiovisual integration and overlapping but distinct resources compared to unimodal Stroop tasks.

Project description:The cortical processing of auditory-alone, visual-alone, and audiovisual speech information is temporally and spatially distributed, and functional magnetic resonance imaging (fMRI) cannot adequately resolve its temporal dynamics. In order to investigate a hypothesized spatiotemporal organization for audiovisual speech processing circuits, event-related potentials (ERPs) were recorded using electroencephalography (EEG). Stimuli were congruent audiovisual/ba/, incongruent auditory/ba/synchronized with visual/ga/, auditory-only/ba/, and visual-only/ba/and/ga/. Current density reconstructions (CDRs) of the ERP data were computed across the latency interval of 50-250 ms. The CDRs demonstrated complex spatiotemporal activation patterns that differed across stimulus conditions. The hypothesized circuit that was investigated here comprised initial integration of audiovisual speech by the middle superior temporal sulcus (STS), followed by recruitment of the intraparietal sulcus (IPS), followed by activation of Broca's area [Miller, L.M., d'Esposito, M., 2005. Perceptual fusion and stimulus coincidence in the cross-modal integration of speech. Journal of Neuroscience 25, 5884-5893]. The importance of spatiotemporally sensitive measures in evaluating processing pathways was demonstrated. Results showed, strikingly, early (<100 ms) and simultaneous activations in areas of the supramarginal and angular gyrus (SMG/AG), the IPS, the inferior frontal gyrus, and the dorsolateral prefrontal cortex. Also, emergent left hemisphere SMG/AG activation, not predicted based on the unisensory stimulus conditions was observed at approximately 160 to 220 ms. The STS was neither the earliest nor most prominent activation site, although it is frequently considered the sine qua non of audiovisual speech integration. As discussed here, the relatively late activity of the SMG/AG solely under audiovisual conditions is a possible candidate audiovisual speech integration response.

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Crossmodal interactions in audiovisual emotion processing.

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