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SAXS/WAXS Investigation of Amyloid-β(16-22) Peptide Nanotubes.


ABSTRACT: This brief report presents an X-ray scattering investigation of self-assembled nanotubes formed by a short peptide. X-ray scattering methods enable multiscale structural elucidation of these nanotubes in solution under the same conditions involved in the self-assembly process. In particular, the dimensions of nanotubes and the crystalline organization within their walls can be determined quantitatively. This is illustrated in the case of amyloid-β(16-22) peptide nanotubes.

SUBMITTER: Narayanan T 

PROVIDER: S-EPMC8024549 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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SAXS/WAXS Investigation of Amyloid-β(16-22) Peptide Nanotubes.

Narayanan Theyencheri T   Rüter Axel A   Olsson Ulf U  

Frontiers in bioengineering and biotechnology 20210324


This brief report presents an X-ray scattering investigation of self-assembled nanotubes formed by a short peptide. X-ray scattering methods enable multiscale structural elucidation of these nanotubes in solution under the same conditions involved in the self-assembly process. In particular, the dimensions of nanotubes and the crystalline organization within their walls can be determined quantitatively. This is illustrated in the case of amyloid-β(16-22) peptide nanotubes. ...[more]

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