Ontology highlight
ABSTRACT:
SUBMITTER: Flores-Mendoza G
PROVIDER: S-EPMC8024570 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Flores-Mendoza Giovanna G Rodríguez-Rodríguez Noé N Rubio Rosa M RM Madera-Salcedo Iris K IK Rosetti Florencia F Crispín José C JC
Frontiers in immunology 20210324
Activation of self-reactive CD8<sup>+</sup> T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of <i>Fas</i> and <i>Fasl</i> causes the accumulation of double-negative (DN; CD3<sup>+</sup> TCR-αβ<sup>+</sup> CD4<sup>-</sup> CD8<sup>-</sup>) T cells that have been proposed to derive from CD8<sup>+</sup> cells, we decided to explore the role of Fas and FasL in self-antigen-induced CD8 downregulation. To this end, we quantified Fas and ...[more]