Ontology highlight
ABSTRACT:
SUBMITTER: Mammadli M
PROVIDER: S-EPMC8024657 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Mammadli Mahinbanu M Huang Weishan W Harris Rebecca R Xiong Hui H Weeks Samuel S May Adriana A Gentile Teresa T Henty-Ridilla Jessica J Waickman Adam T AT August Avery A Bah Alaji A Karimi Mobin M
iScience 20210311 4
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematological malignancies, due to graft-versus-leukemia (GVL) activity mediated by alloreactive donor T cells. However, graft-versus-host disease (GVHD) is also mediated by these cells. Here, we assessed the effect of attenuating TCR-mediated SLP76:ITK interaction in GVL vs. GVHD effects after allo-HSCT. CD8<sup>+</sup> and CD4<sup>+</sup> donor T cells from mice expressing a Y145F mutation in SLP-76 did no ...[more]