SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.

ABSTRACT: Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal cancer (CRC). However, the precise upstream regulatory mechanisms of hTERT in different cancer types remain poorly understood. Here, we uncovered the candidate transcriptional factor of hTERT in CRC and explored its role and the corresponding molecular mechanisms in regulating hTERT expression and CRC survival with an aim of developing mechanism-based combinational targeting therapy. The possible binding proteins at the hTERT promoter were uncovered using pull-down/mass spectrometry analysis. The regulation of SPT6 on hTERT expression and CRC survival was evaluated in human CRC cell lines and mouse models. Mechanistic studies focusing on the synergy be

SUBMITTER: Diao C 

PROVIDER: S-EPMC8024721 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature