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New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26.

ABSTRACT: Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1-4 showed inhibitory activities against nitric oxide (NO) with IC₅₀ values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.

SUBMITTER: Pan G

PROVIDER: S-EPMC8025228 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26.

Pan Guojun G Li Yanling Y Che Xinyu X Tian Dan D Han Wenjie W Wang Zimin Z Zhao Yanfen Y Ren Shuang S Xu Yiru Y Hao Gangping G Guo Mengfei M Xiao Na N Kong Fandong F

Frontiers in microbiology 20210325

Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H ...[more]

PMID: 33841388

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