Epigenetics in blood-brain barrier disruption.
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ABSTRACT:
SUBMITTER: Ihezie SA
PROVIDER: S-EPMC8025355 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Epigenetics in blood-brain barrier disruption.
Ihezie Stephanie A SA Mathew Iny Elizebeth IE McBride Devin W DW Dienel Ari A Blackburn Spiros L SL Thankamani Pandit Peeyush Kumar PK
Fluids and barriers of the CNS 20210406 1
The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transporters, and limited endocytosis which combine to protect the brain from toxins and maintains brain homeostasis. Blood-brain barrier (BBB) leakage is a serious secondary injury in various CNS disorders like stroke, brain tumors, and neurodegenerative disorders. Currently, there are no drugs o ...[more]
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