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Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores.

ABSTRACT: A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H+, Na+) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases.

SUBMITTER: Sahoo S 

PROVIDER: S-EPMC8025732 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores.

Sahoo Subhasish S   Ur Rehman Jawad J   Shah Muhammad Raza MR   De Priyadarsi P   Tecilla Paolo P  

ACS applied polymer materials 20210104 2

A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H<sup>+</sup>, Na  ...[more]