Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial.

ABSTRACT:

Background

Remote ischemic conditioning (RIC) is a promising technique that may protect organs and tissues from the effects of additional ischemic episodes. However, the therapeutic efficacy of RIC in humans with sepsis remains unknown. We hypothesized that RIC might improve sublingual microcirculation in patients with sepsis.

Methods

This prospective single-arm trial was performed in a mixed ICU at a tertiary teaching hospital. We included patients with sepsis or septic shock within 24 h of ICU admission. The RIC procedure comprised 3 cycles of brachial cuff inflation to 200 mmHg for 5 min followed by deflation to 0 mmHg for another 5 min. The procedure took 30 min. RIC was performed at the time of study inclusion and repeated after 12 and 24 h. Sublingual microcirculatory

SUBMITTER: Kiudulaite I 

PROVIDER: S-EPMC8025901 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature