Ontology highlight
ABSTRACT:
SUBMITTER: Tennakoon M
PROVIDER: S-EPMC8026654 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Tennakoon Mithila M Senarath Kanishka K Kankanamge Dinesh D Ratnayake Kasun K Wijayaratna Dhanushan D Olupothage Koshala K Ubeysinghe Sithurandi S Martins-Cannavino Kimberly K Hébert Terence E TE Karunarathne Ajith A
Cellular signalling 20210211
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the inner leaflet of the plasma membrane. Though the initial focus was mainly on Gα-mediated events, Gβγ subunits were later identified as major contributors to GPCR-G protein signalling. A broad functional array of Gβγ signalling has recently been attributed to Gβ and Gγ subtype diversity, comprising 5 Gβ and 12 Gγ ...[more]