Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC8027031 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Lee Sun Hee SH Hyeon Do Young DY Yoon Soo-Hyun SH Jeong Ji-Hak JH Han Saeng-Myung SM Jang Ju-Won JW Nguyen Minh Phuong MP Chi Xin-Zi XZ An Sojin S Hyun Kyung-Gi KG Jung Hee-Jung HJ Song Ji-Joon JJ Bae Suk-Chul SC Kim Woo-Ho WH Hwang Daehee D Lee You Mie YM
Cell death and differentiation 20201028 4
Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation of RUNX3 under hypoxia is still not fully understood. Here, we demonstrate a mechanism that G9a, lysine-specific methyltransferase (KMT), modulates RUNX3 through PTM under hypoxia. Hypoxia significantly increased G9a protein level and G9a interacted with RUNX3 Runt domain, which led to ...[more]