Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains.
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ABSTRACT:
SUBMITTER: Dai J
PROVIDER: S-EPMC8027124 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains.
Dai Jiacheng J Chen Yu Y Dai Rujia R Jiang Yi Y Tian Jianghua J Liu Sihan S Xu Meng M Li Miao M Zhou Jiaqi J Liu Chunyu C Chen Chao C
Frontiers in neuroscience 20210325
Agonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Our study used gene expression data of 262 samples from ROSMAP with the detailed terminal state recorded for each donor, such as fever, infection, and unconsciousness. Fever and infection were the primary contributors to brain gene expression changes, brain cell-type-specific gene expression, and cell proportion changes. Furthermore, we also f ...[more]
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