MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke.
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ABSTRACT:
SUBMITTER: Hernandez-Guillamon M
PROVIDER: S-EPMC8029059 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
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MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke.
Hernandez-Guillamon Mar M Martinez-Saez Elena E Delgado Pilar P Domingues-Montanari Sophie S Boada Cristina C Penalba Anna A Boada Mercè M Pagola Jorge J Maisterra Olga O Rodriguez-Luna David D Molina Carlos A CA Rovira Alex A Alvarez-Sabin José J Ortega-Aznar Arantxa A Montaner Joan J
Brain pathology (Zurich, Switzerland) 20110915 2
Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly. Matrix metalloproteinases (MMPs) have been implicated in blood-brain barrier disruption and ICH pathogenesis. In this study, we determined the levels MMP-2 and MMP-9 in plasma and their brain expression in CAA-associated hemorrhagic stroke. Although MMP-2 and MMP-9 plasma levels did not differ among patients and controls, their brain expression was increased in perihematoma areas of CAA- ...[more]
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