An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects.
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ABSTRACT:
SUBMITTER: Yamasaki AE
PROVIDER: S-EPMC8031422 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects.
Yamasaki Amanda E AE Warshaw Jane N JN Kyalwazi Beverly L BL Matsui Hiroko H Jepsen Kristen K Panopoulos Athanasia D AD
Stem cell research 20201123
Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of an iPSC line from a human immortalized acute myeloid leukemia (AML) cell line, the cell line HL-60. This iPSC line retains a majority of the leukemic genotype and displays defects in myeloid differentiation, thus providing a tool for modeling and ...[more]
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