Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [¹¹C]PBR28 in Elderly Individuals Without Dementia.

ABSTRACT:

Objective

To examine whether early β-amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.

Methods

We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [¹¹C]PBR28 to assess neuroinflammation and with [¹¹C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [¹¹C]PBR28 and [¹¹C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, respectively. Fasting venous glucose, insulin, and high-sensitivity C-reactive protein (hs-CRP) values were determined. Homeostatic

SUBMITTER: Toppala S 

PROVIDER: S-EPMC8032368 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature