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Diagnostic accuracy of urinary aquaporin-1 as a biomarker for renal cell carcinoma.


ABSTRACT:

Introduction

Optimal patient selection plays a vital role in management of renal tumors with the introduction of nephron-sparing approaches and active surveillance. A reliable and accurate diagnostic biomarker will be a useful adjunct to decision-making. We studied the diagnostic accuracy of urinary aquaporin-1 (uAQP-1), an upcoming urinary biomarker, for renal cell carcinoma.

Materials and methods

In this prospective biomarker study, urine samples were obtained preoperatively from 36 patients with an imaged renal mass suggestive of RCC and 24 healthy age-matched controls, chosen from among voluntary kidney donors. uAQP-1 concentrations were estimated with a sensitive and specific enzyme-linked immunosorbent assay (ELISA) and normalized by estimation of urinary creatinine. The Mann-Whitney U-test was used to compare differences between any two groups. A receiver operator characteristic (ROC) curve was plotted to analyze the diagnostic accuracy of uAQP-1 for RCC.

Results

The median uAQP-1 concentration among the cases and controls was 8.78 ng/mg creatinine (interquartile range [IQR]: 5.56-12.67) and 9.52 ng/mg creatinine (IQR: 5.55-12.45), respectively. There was no significant difference in uAQP-1 concentrations between the two groups. ROC analysis showed that, for a cutoff value of 8 ng/mg creatinine, the sensitivity and specificity of uAQP-1 as a diagnostic test were 47.2% and 66.7%, respectively, and area under the curve was 0.52 (95% confidence interval: 0.42-0.62).

Conclusions

uAQP-1 concentrations did not discriminate between healthy individuals and patients with RCC. The results of this study suggest that uAQP-1 may not be a suitable diagnostic biomarker for RCC in the study population.

SUBMITTER: Cheriyan A 

PROVIDER: S-EPMC8033244 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature

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Diagnostic accuracy of urinary aquaporin-1 as a biomarker for renal cell carcinoma.

Cheriyan Abhilash A   Nellickal Arun Jose AJ   John Nirmal Thampi NT   Jeyaseelan Lakshmanan L   Kumar Santosh S   Devasia Antony A   Kekre Nitin N  

Indian journal of urology : IJU : journal of the Urological Society of India 20210101 1


<h4>Introduction</h4>Optimal patient selection plays a vital role in management of renal tumors with the introduction of nephron-sparing approaches and active surveillance. A reliable and accurate diagnostic biomarker will be a useful adjunct to decision-making. We studied the diagnostic accuracy of urinary aquaporin-1 (uAQP-1), an upcoming urinary biomarker, for renal cell carcinoma.<h4>Materials and methods</h4>In this prospective biomarker study, urine samples were obtained preoperatively fro  ...[more]

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