Ontology highlight
ABSTRACT:
SUBMITTER: Kimura A
PROVIDER: S-EPMC8034574 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Kimura Akihiko A Kagawa Tatehiro T Takei Hajime H Maruo Yoshihiro Y Sakugawa Hiroshi H Sasaki Takahiro T Murai Tsuyoshi T Naritaka Nakayuki N Takikawa Hajime H Nittono Hiroshi H
Hepatology communications 20201231 4
Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [<i>SLCO1B1</i>]) and OATP1B3 (<i>SLCO1B3</i>) serve as transporters for hepatic uptake of important endogenous substances and several commonly prescribed drugs. Inactivation of both proteins together causes Rotor syndrome. How this OATP1B1/1B3 defect disturbs bile acid (BA) metabolism is largely unknown. In this study, we performed detailed BA analysis in 3 patients with genetical ...[more]